The following questions are based on data, graphs, and figures from the following article: Naphthoquinone-mediated Inhibition of Lysine Acetyltransferase KAT3B/p300, Basis for Non-toxic Inhibitor Synthesis. Mohankrishna Dalvoy Vasudevarao et al. The Journal of Biological Chemistry, 289, 7702-7717. March 14, 2014 . doi: 10.1074/jbc.M113.486522
A. For RNA polymerase to transcribe DNA that is packed in a nucleosome, what must likely happen to the nucleosome complex?
The DNA must unwind from the histone core of then nucleosome to allow binding of transcription factors and ultimately RNA polymerase to the regulatory regions of the DNA (promoter, etc). Otherwise DNA-dependent RNA polymerization will not occur.