Backbone and sidechains of MDB1 protein
Cartoon, Hbonds and
Wireframe
Active site residues (Val 20, Arg 22, Tyr 34, Arg 44, Ser 45)
MDB1 is able to bind to methylated DNA through the use of 5 highly conserved
side chains.
Methylated DNA (methyl groups in yellow) and MDB1 active site residues (Val 20, Arg 22, Tyr 34, Arg 44, Ser 45)
Loop L1 (residues 22-30)
This loop undergoes a conformational change to allow it to bind to the major
groove of DNA.
Methylated DNA and binding site of MDB1 (Loop L1)
Methylated DNA with binding MDB1 and active site.
The L1 loop binds to DNA and the active site is then able to interact with the
methyl groups present.