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Introduction
EmrM is a prototype of the Small Multi-drug Resistance family of efflux transporters and actively expels positively charged hydrophobic drugs across the inner membrane of Escherichia coli.
Wire
Frame
Backbone
Backbone and sidechains
Cartoon, Hbonds and
Wireframe
Cartoon and TPP
Two EmrE polypeptides form a homodimeric transporter that binds substrate (tetraphenylphosphonium, TPP) at the dimerization interface.
Wireframe with Leu-7, Tyr-60, and Trp-63 spacefilled and TPP cartoon
Leu-7, Tyr-60, and Trp-63 are residues that are important for drug transport because they perform essential structural roles.
Cartoon with Glu-14 spacefilled and TPP cartoon
TPP first binds to Glu-14 in one subunit of the dimer in exchange for a proton.
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