Mechanism of auxin perception by the TIR1 ubiquitin ligase
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Wire Frame
in chains' colors
Three
chains in the protein: Chain A - gray, Chain B -
green, Chain C -
red
Cartoon
Secondary structure of protein
alpha helixes and beta sheets
Wireframe Auxin + Backbone Protein
Naphtalene-1-acetic acid (spacefill), a synthetic auxin (a mimetic of the most important auxin, indole acetic acid) and the backbone of protein
Temperature presentation of Protein with Auxin
The more mobile, "warmer" segments are
colored red, progressing to more immobile blue
fragments. NLA in spacefill.
Auxin interaction with protein
Chain B amino acids-green: HIS78, ARG403, SER438,
SER462, GLU487, Chain C amino acids-red: PRO7, and TRP 5
interacting with NLA.
Solvent surface
Protein and Auxin with
water (1.4 A) around the
molecule.
MEP for protein
The
Map of Electrostatic Potential (MEP) shows
the charge distribution (δ+and
+ charges which show as blue, and the
δ-
and - charges which show as
red) on the atoms of the
macromolecules. Black spacefill is
NLA.
Tan, X., Calderon-Villalobos,
L.I.A., Sharon,
M., Zheng,
C., Robinson,
C.V., Estelle,
M., Zheng,
N.
(2007) Mechanism of auxin perception by the TIR1 ubiquitin
ligase
Nature
446: 640-645
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