Peptidoglycan glycosyltransferase is an enzyme
required for bacterial cell wall synthesis. It catalyzes the
formation of peptidoglycan from disaccharide subunits on the bacterial cell surface.
Note that the structure of this enzyme is
composed completely of alpha helices with no beta sheets.
Cartoon and Wireframe
solvent accessible surface: dots
The next surface display is solid and require calculations with some time delays
Electrostatic potential on top of a wireframe rendering of the
This enzyme is
found on the surface of the cell membrane, which means that the
enzyme would be positively charged where it interacts with the
membrane (yellow and green areas). The catalytic site is
represented by the dark blue area of the map.
with residues lining catalytic site: Glu 83 and
These side chains have been identified as key players in the catalytic activity of the enzyme,
though their exact roles are not yet fully understood.
The ligand for peptidoglycan glycosyltransferase is penicillin. As of right now, no crystal structure of the ligand-bound enzyme complex is available.