Report for Lab 5: Molecular Modeling 2 - Central Dogma of Biology
NAMES: _____________ _______________
Write a few sentences describing the salient features of the following models that you viewed today.
Name the genetic disease, the name of the gene, and the chromosomal location of thee gene that you selected.
Lab Exercise 4:
Write a few sentences describing the salient features of the following models that you viewed today.:
1. Protein: Antiviral Drug Complex: 1HSG:
2. Protein/DNA complex
3. Protein/Radiciol (antitumor, antibiotic) complex
4. Thrombin:Hirudin complex
Central Dogma of Biology:
Below is a section of DNA which codes for part of a protein. The bottom (blue) strand in this example is the template strand, which is also called the minus (-) strand,or the sense strand. It is this strand that serves as a template for the mRNA synthesis. The enzyme RNA polymerase sythesizes an mRNA in the 5' to 3' direction complementary to the template strand. The opposite DNA strand (red) is called the coding strand, the nontemplate strand, the strand, the plus (+) strand, or the antisense strand.
1 2 3 4 MUTATIONS: G A T T 5' C C C C T G G A A C A G T G G A C A G C A G G A 3' 3' G G G G A C C T T G T C A C C T G T C G T C C T 5'
a. Write the mRNA sequence. Use the genetic code found below.
b. Write the amino acid sequence.
c. Consider the mutations shown in the top line. Suppose the single mutation 1 (T - G) occurs in the 5' to 3' strand, with a concomitant change in the coding strand, write the amino acid sequence for the new protein.
d. Repeat (c), but with mutation 2 instead.
e. Repeat (c), but with mutation 3 instead.
f. Repeat (c), but with mutation 4 instead.