Stephen G. Saupe - Biology Department, College of St. Benedict/St. John's University, Collegeville, MN 56321; (320) 363-2782; ssaupe@csbsju.edu |
Gink & Go in the Kitchen (a look at the Central Dogma)
Setting: Go is in the dormitory kitchen making brownies. Gink enters.
Gink: | Hey Go, whazzup? | |
Go: | I’m making some brownies for a treat after I finish studying biology. Isn't transcription and translation really cool? | |
Gink: | I hate that stuff. But I loved Saupe’s barbecued cat analogy. He finally said something intelligent. | |
Go: | Well, I thought it was awful and tasteless. | |
Gink: | Good pun dude. You have to admit that it makes sense if you think of the nucleus as a reference library where none of the books are allowed to circulate. | |
Go: | Right. And the books are analogous to the hereditary information; the DNA. | |
Gink: | So if we need a recipe for something like, say barbequed cat, then we have to go to the shelves and find the “Dead Cat Cookbook.” | |
Go: | But unfortunately we can’t this book out of the library. | |
Gink: | We could always razor blade the recipe out of the book; the librarians would never know. | |
Go: | Crikey – that’s a bigger crime than one of Saupe’s lectures! Don’t ever, ever…. | |
Gink: | Relax, you’re shorts are a little too tight. I’m kidding. I would never do that. | |
Go: | Phew.….anyway, then we would make a photocopy of the recipe. | |
Gink: | Yeah, and that’s just like process of transcription. | |
Go: | Only this photocopy of the original DNA is now messenger RNA. | |
Gink: | We can then take the recipe back to our kitchen to whip up a tasty feline treat. | |
Go: | Um, right. Well, the kitchen is analogous to the ribosome where proteins are made. | |
Gink: | And that’s called translation. I don’t know why they have to make up new terms for something as simple as saying, protein synthesis. | |
Go: | Good point. But the important thing is we’ve now modeled the Central Dogma. | |
Gink: | I’ve never heard of that breed of dog…is it like a Wiener Dogma? | |
Go: | No bozo – you know that Francis Crick first suggested this model to explain how DNA codes for proteins. | |
Gink: | Yeah, yeah. DNA gets transcribed in the nucleus to RNA which, in turn, gets translated at the ribosomes to make proteins. | |
Go: | Marvelous….don't you like the word 'marvelous'? Now let's talk about the tasty details of how transcription and translation occur. | |
Gink: | Spare me, dude…..just gimme a couple of those brownies so I can go “Dance with the Stars!” |
Exercises: Answer the following questions when you complete the dialog.
Define: transcription, translation and replication
Indicate where in the cell each process occurs.
What is the Central Dogma?
How does the genotype relate to the phenotype?
Can DNA be a product of the Central Dogma? Can RNA be a product? protein?
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Last updated: December 05, 2006
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