Publications:
  1. Graham, K. J.; Johnson, B. J.; Jones, T. N.; McIntee, E. J.; Schaller, C. P. Open-ended Purification Schemes for an Organic Chemistry Laboratory Practical J. Chem. Ed. Accepted for Publication
    2.
  2. Upadhyaya, P.; McIntee, E. J.; Villalta, P. W.; Hecht, S. S., Identification of Adducts Formed in the Reaction of 5'-Acetoxy-N'-Nitrosonornicotine with Deoxyguanosine and DNA Chem. Res. Toxicol. 2006, 19, 426-435.
  3. Conaway, C. Clifford; Wang, Chung-Xiou; Pittman, Brian; Yang, Yang-Ming; Schwartz, Joel E.; Tian, Defa; McIntee, Edward J.; Hecht, Stephen S.; Chung, Fung-Lung, Phenethyl Isothiocyanate and Sulforaphane and Their N-Acetylcysteine Conjugates Inhibit Malignant Progression of Lung Adenomas Induced by Tobacco Carcinogens in A/J Mice. Cancer Research 2005, 65, 8548-8557.

  4. Jalas, J.R; McIntee, E. J.; Kenney, P. M. J.; Upadhyaya, P.; Peterson, L. A.; Hecht, S. S.: Stereospecific Deuterium Substitution Attenuates the Tumorigenicity and Metabolism of the Tobacco-Specific Nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Chem. Res. Toxicol. 2003, 16, 794-806.

  5. Wang, M; Cheng, G; Sturla, S. J.; Shi, Y.; McIntee, E. J.; Villalta, P. W.; Upadhyaya, P; Hecht, S. S. Identification of Adducts Formed by Pyridyloxobutylation of Deoxyguanosine and DNA by 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a Chemically Activated form of Tobacco Specific Carcinogens. Chem. Res. Toxicol. 2003, 16, 616-626.

  6. Cheng, G.; Shi, Y.; Sturla, S. J.; Jalas, J. R.; McIntee, E. J.; Villalta, P. W.; Wang, M.; Hecht, S. S. Reactions of Formaldehyde plus Acetaldehyde with Deoxyguanosine and DNA: Formation of Cyclic Deoxyguanosine Adducts and Formaldehyde Cross-Links. Chem. Res. Toxicol. 2003, 16, 145-152.

  7. Hecht, S.S.; Upadhyaya, P.; Wang, M.; Bliss, R.L.; McIntee, E.J.; Kenney, P.M.J. Inhibition of Lung Tumorigenesis in A/J Mice by N-Acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and Myo-Inositol, Individually and in Combination. Carcinogenesis 2002, 23, 1455-1461.

  8. Hecht, S.S.; McIntee, E.J.; Cheng, G.; Shi, Y.; Villalta, P.W.; Wang, M. New Aspects of DNA Adduct Formation by the Carcinogens Crotonaldehyde and Acetaldehyde. In: Biological Reactive Intermediates VI: Chemical and Biological Mechanisms in Susceptibility to and Prevention of Environmental Disease (R. Synder et al., eds.), Kluwer Academic/Plenum Publishers, 2001 pg 63-71.

  9. Hecht, S.S.; McIntee, E.J.; Wang, M. New DNA Adducts of Crotonaldehyde and Acetaldehyde. Toxicology 2001, 166, 31-36.

  10. McIntee, E.J. and Wagner, C.R. Amino Acid Phosphoramidate Nucleosides: Potential ADEPT/GDEPT Substrates. Bioorganic & Medicinal Chemistry Letters 2001, 11, 2803-2805.

  11. Wang, M.; McIntee, E.J.; Cheng, G.; Shi, Y.; Villalta, P.; Hecht, S.S. Reactions of 2,6-Dimethyl-1,3-dioxane-4-ol (Aldoxane) with Deoxyguanosine and DNA. Chem. Res. Toxicol. 2001, 14, 1025-1032.

  12. Wang, M.; McIntee, E.J.; Shi, Y.; Cheng, G.; Upadhyaya, P.; Villalta, P.; Hecht, S.S. Reactions of a -Acetoxy-N-nitrosopyrrolidine with Deoxyguanosine and DNA. Chem. Res. Toxicol. 2001, 14, 1435-1445.

  13. Upadhyaya, P.; McIntee, E.J.; Hecht, S.S. Preparation of Pyridine-N-Glucuronides of Tobacco-Specific Nitrosamines. Chem. Res. Toxicol. 2001, 14, 555-561.

  14. Wang, M.; McIntee, E.J.; Cheng, G.; Shi, Y.; Villalta, P.; Hecht, S.S. A Schiff Base is a Major DNA Adduct of Crotonaldehyde. Chem. Res. Toxicol. 2001, 14, 423-430.

  15. Murphy, S.E.; Isaac, I.S.; Ding, X.; McIntee, E.J. Specificity of Cytochrome P450 2A3-Catalyzed a-Hydroxylation of N'-Nitrosonornicotine Enantiomers. Drug Metab. Dispos. 2000, 28, 1263-1266.

  16. Wang, M.; McIntee, E.J.; Cheng, G.; Shi, Y.; Villalta, P.; Hecht, S.S. Identification of Paraldol-Deoxyguanosine Adducts in DNA Reacted with Crotonaldehyde. Chem. Res. Toxicol. 2000, 13, 1065-1074.

  17. Wang, M.; McIntee, E.J.; Cheng, G.; Shi, Y.; Villalta, P.; Hecht, S.S. Identification of DNA Adducts of Acetaldehyde. Chem. Res. Toxicol. 2000, 13, 1149-1157.

  18. Iyer, V.V.; Griesgraber, G.W.; Radmer, M.R.; McIntee, E.J.; Wagner, C.R. Synthesis, In Vitro Anti-Breast Cancer Activity and Intracellular Decomposition of Amino Acid Methyl Ester and Alkyl Amide Phosphoramidate Monoesters of 3'-Azido-2', 3'-Dideoxythymidine (AZT). J. Med. Chem. 2000, 43, 2266-2274.

  19. Wagner, C.R.; Iyer, V.V.; McIntee, E.J. Pronucleotides: Toward the In Vivo Delivery of Antiviral and Anticancer Nucleotides. Medicinal Research Reviews 2000, 6, 417-451.

  20. Carmella, S.G.; McIntee, E.J.; Chen, M.; Hecht, S.S. Enantiomeric Composition of N'-Nitrosonornicotine and N'-Nitrosoanatabine in Tobacco. Carcinogenesis 2000, 21, 839-843.

  21. McIntee, E.J. and Hecht, S.S. Metabolism of N'-Nitrosonornicotine Enantiomers by Cultured Rat Esophagus and in vivo in Rats. Chem. Res. Toxicol. 2000, 13, 192-199.

  22. Wagner, C.R.; Chang, S.-L.; Griesgraber, G.W.; Song, H.; McIntee, E.J.; Zimmerman, C.L. Antiviral Nucleoside Drug Delivery Via Amino Acid Phosphoramidates. Nucleosides & Nucleotides 1999, 18, 913-919.

  23. Abraham, T.W.; McIntee, E.J.; Iyer, V.V.; Schinazi, R.F.; Wagner, C.R. Synthesis, Biological Activity and Decomposition Studies of Amino Acid Phosphomonoester Amidates of Acyclovir. Nucleosides & Nucleotides 1997, 10, 2079-2092.

  24. McIntee, E.J.; Remmel, R.P.; Schinazi, R.F.; Abraham, T.W.; Wagner, C.R. Probing the Mechanism of Action and Decomposition of Amino Acid Phosphomonoester Amidates of Antiviral Nucleoside Prodrugs. J. Med. Chem. 1997, 40, 3323-3331.

  25. Ballato, G.; Akanni, A.O.; McIntee, E.J.; Larson, R.S.; Chang, S.-L.; Abul-Hajj, Y.J.; Wagner, C.R. Potent Growth Inhibitory Activity of Zidovudine (AZT) on Cultured Human Breast Cancer Cells and Rat Mammary Tumors. Cancer Research 1997, 57, 2341-2345.

  26. Abraham, T.W.; Kalman, T.I.; McIntee, E.J.; Wagner, C.R. Synthesis and Biological Activity of Aromatic Amino Acid Phosphoramidates of 5-Fluoro-2'-deoxyuridine and 1-b-Arabinofuranosylcytosine: Evidence of Phosphoramidase Activity. J. Med. Chem. 1996, 39, 4569-4575.

  27. Wagner, C.R.; McIntee, E.J.; Schinazi, R.F.; Abraham, T.W. Aromatic Amino Acid Phosphoramidate Di- and Triesters of 3'-Azido-3'-Deoxythymidine (AZT) Are Non-Toxic Inhibitors of HIV-1 Replication. Bioorganic & Medicinal Chemistry Letters 1995, 5, 1819-1824.

  28. Subasinghe, N.L.; Bontems, R.J.; McIntee, E.J., Mishra, R.K.; Johnson, R.L. Bicyclic Thiazolidine Lactam Peptidomimetics of the Dopamine Receptor Modulating Peptide Pro-Leu-Gly-NH2. J. Med. Chem. 1993, 36, 2356-2361.

Abstracts:

  1. Graham, Kate J.; Johnson, Brian J.; Jones, T. Nicholas; McIntee, Edward J. Open-ended purification schemes for organic chemistry laboratory practical. Book of Abstracts, 229th ACS National Meeting, 2005

  2. Wang, M.; McIntee, E.J.; Cheng, G.; Shi, Y.; Villalta, P.; Hecht, S.S. Characterization of Paraldol-Releasing Adducts of Crotonaldehyde. Book of Abstracts, 219th ACS National Meeting 2000, Abstract #TOXI-061.

  3. Wang, M.; McIntee, E.J.; Cheng, G.; Shi, Y.; Villalta, P.; Hecht, S.S. New DNA Adducts of Acetaldehyde. Scientific Proceedings 91st Annual Meeting of the American Association for Cancer Research 2000, 41, Abstract #606, p95.

  4. Carmella, S.G.; McIntee, E.J.; Chen, M.; Hecht, S.S. Enantiomeric Composition of N' Nitrosonornicotine and N'-Nitrosoanatabine in Tobacco. Scientific Proceedings 91st Annual Meeting of the American Association for Cancer Research 2000, 41, Abstract #5329, p839.

  5. Wang, M.; Shi, Y.; McIntee, E.J.; Cheng, G.; Hecht, S.S. DNA Adduct Formation by 2-Butenal (Crotonaldehyde). Scientific Proceedings 90th Annual Meeting of the American Association for Cancer Research 1999, 40, Abstract #319, p48.

  6. Wagner, C.R.; McIntee, E.J.; Chiang, P.K. Amino Acid Phosphoramidates of Antiviral 3-Deaza-Adenosine Analogs Exhibit High Potency and Low Toxicity. Antiviral Research 1998, 37, pA52.

  7. Wagner, C.R.; McIntee, E.J.; Song, H.; Zimmerman, C.L. Comparison of the Plasma Pharmacokinetics of AZT And AZT Phosphoramidates. Antiviral Research 1998, 37, pA63

  8. Wagner, C.R.; McIntee, E.J.; Chang, S.-L.; Zimmerman, C.L. Antiviral Nucleotide Drug Delivery via Amino Acid Phosphoramidates. FASEB Journal 1997, 11, pA836.

  9. Wagner, C.R.; Kalman, T.I.; McIntee, E.J.; Abraham, T.W. Evidence of Phosphoramidase Activation of Amino Acid Phosphoramidate Prodrugs of an Antitumor Nucleoside. XII International Roundtable: Nucleosides, Nucleotides And Their Biological Applications; Making Drugs Out of Nucleosides and Oligonucleotides 1996, Abstract #PPII 83, p267.

  10. McIntee, E.J.; Remmel, R.P.; Schinazi, R.F.; Wagner, C.R. Potential Novel Mechanism for Inhibition of HIV Replication by Aromatic Amino Acid Phosphoramidates of Zidovudine (AZT). Keystone Symposia on Molecular and Cellular Biology, Molecular Biology of HIV 1996, Abstract #113, p20.

  11. Nielsen, J.M.; Chang, S.-L.; McIntee, E.J.; Wagner, C.R. Expression and Phage Display of a SCA Constructed from the Phosphorylcholine Binding IG-A, MOPC-167. FASEB Journal 1995, 9, Abstract #1147, pA1454.