Wire frame model of protein

Protein with Cholesterol and Palmitic acid ligands bound -These secure the protein as a dimer form in a plasma membrane and show the membrane disposition of the protein.

Protein with bound ligand Carazolol, a high affinity antagonist

Protein with Proline residues - proline induces kinks at conserved positions along the span of the transmembrane segments which are thought to enable the structural rearrangements required for activation of G protein effectors

(The next surface displays are solid and require calculations with some time delays)

solvent excluded molecular surface - (solid 1.4 A) - surface at contact with sphere (molecular) - with bound cholesterol and palmitic acid

Map of Electrostatic potential from a .pqb and .jvxl map files with wireframe rendering - Displays non-polar region (green) where the protein is embedded in a membrane, and the binding site (red) is negatively charged. (May have to refresh page in order to view this.)

Carazolol binding site in yellow: Ser204, Tyr199, Ser203, Ser207, Phe193, Asp113, Trp109, Tyr316, Trp286, Asn312, Phe289, Tyr308, Phe290, Asn293