Toll-Like Receptor 3
Complex with dsRNA
The Toll-Like Receptor 3 (TLR3) is part of a family of integral membrane receptors that recognize pathogen-associated molecular signatures. TLR3 ectodomain binds dsRNA initiating a signaling cascade resulting in a inflammatory response.
This structure does NOT contain the
Wire Frame Model of TLR3 ectodomain complex with dsRNA
illustrating dimerized Ectodomains
residues on single monomer required for binding
Backbone and side chains of TLR3 ecodomain
Mixed rendering showing the TLR3 in cartoon form and dsRNA in space filling form
excluded molecular surface
- (solid 1.4 A) - surface at contact with sphere (molecular)
region of TLR3 ectodomain that binds dsRNA (wireframe CPK)
Lin Liu, Istvan Botos, Yan Wang, Joshua N. Leonard, Joseph Shiloach, David M. Segal, David R. Davies. Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA. Science. Vol 320. 18 April 2008.