Biochemistry Online: An Approach Based on Chemical Logic

Biochemistry Online


B:  More Complex Carbohydrates


Learning Goals/Objectives for Chapter 3B:  After class and this reading, students will be able to

  • state the differences between the homopolysaccharides glycogen, starch cellulose, and chitin and those with dissacharide repeat units (glycosoaminoglycans)
  • draw cartoon models of complex oligosaccharides such as peptidoglycans of bacterial cell walls, N and O linked glycoproteins, and proteoglycans showing the linkage of protein and CHO
  • describe the role of protein and cell surface CHO in binding and biological function
  • given diagrams of leukocyte and endothelial cells interactions, describe the role of selectins, selectin ligands, integrins and cellular adhesion molecules in immune cell/blood vessel interactions.

This chapter on complex carbohydrates (glycans/glycoconjugates) will review those features that are deemed especially important for a one semester course dealing with structure and function of biomolecules.


B4.  O-linked Glycoproteins

The CHOs are usually attached from a Gal (b 1-3) GalNAc to a Ser or Thr of a protein.

Figure: O-linked Glycoproteins

O linked glycoprotein

The blood group antigens (CHOs on cells attached to either proteins or lipids) are examples . The sugars shown as chairs in the figure below are the blood group antigens (in contrast to structures found in many texts).  They are attached to a core heterosaccharide (shown as red elipse below) which is connected to either a membrane glycoprotein or glycolipid.

Figure: Blood Group Antigens

Blood Group Antigens


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