CHAPTER 3 - CARBOHYDRATES/GLYCANS
B: More Complex Carbohydrates
Learning Goals/Objectives for Chapter 3B: After class and
this reading, students will be able to
- state the differences between the homopolysaccharides
glycogen, starch cellulose, and chitin and those with
dissacharide repeat units (glycosoaminoglycans)
- draw cartoon models of complex oligosaccharides such as
peptidoglycans of bacterial cell walls, N and O linked
glycoproteins, and proteoglycans showing the linkage of protein
- describe the role of protein and cell surface CHO in binding
and biological function
- given diagrams of leukocyte and endothelial cells
interactions, describe the role of selectins, selectin ligands,
integrins and cellular adhesion molecules in immune cell/blood
This chapter on complex carbohydrates (glycans/glycoconjugates) will
review those features that are deemed especially important for a one
semester course dealing with structure and function of biomolecules.
B8. General Links and References
CHO Web Sites
a program for constructing 3D models (unfornuately using Java) of
saccharides from their sequences using standard nomenclature.
mistakes in Biochemistry:
Sander I. van Kasteren, Holger B. Kramer, Henrik H. Jensen, Sandra J.
Campbell, Joanna Kirkpatrick, Neil J. Oldham, Daniel C. Anthony,
Benjamin G. Davis. Expanding the diversity of chemical protein
modification allows post-translational mimicry. Nature,
446, 1105 (2007).
Dzung H. Nguyen, Nancy Hurtado-Ziola,
and Ajit Varki.
Loss of Siglec expression on T lymphocytes during
PNAS May 16, 2006 vol. 103 no. 20 7765-7770
- Cohen, J. Differences in Immune Cell "Brakes" May Explain
Chimp-Human Split on AIDS. Science 312 672 (2006)
Borman, Stu. Carbohydrate Advances. C&E News. August 6, pg 41
Genbacev, O. , et al. Trophoblast
L-Selectin-Mediated Adhesion at the Maternal-Fetal Interface. Science.
299, pg 405 (2003) (Review: Vol 299, pg 355, 2003)
- Schfield et al. Synthetic GPI as a candidate anti-toxic vaccine in a
model of malaria. Nature. 418, pg 785 (2002)
- Samuelson et al. Making Membranes in Bacteria (moving proteins to
the correct location). Nature. 406. pg 575, 637 (2000)
- Seeberger et al. Sugars Join the Automation rush (sold phase
synthesis of oligosaccharides). Science. 291, pg 805 (2001)
- Peters et al. Fusion needs more than SNARES (how membranes fuse).
Nature 409, pg 567 (2001)
- Saxon and Bertozzi. Cell Surface Engineering by a modified
Staudinger reaction. Science. 287. pg 2007 (2000)
- Humprhies et al, Forsberg et al. Mast cell Heparin (role).
Nature. 400, pg 714, 769, 773 (1999)
- Mel�ndez-Hevia et al. Glycogen Structure:
an Evolutionary View",
Medical Implications of Metabolic Control Analysis (ed. A.
Cornish-Bowden and M. L. C�rdenas), Kluwer Academic Publishers,
Dordrecht. pp. 319--326 (2000)
- Helenius et al. Translocation of lipid-linked oligosaccharides
across the ER membrane requires Rft1 protein. Nature. 415. pg 382, 447
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More Complex Carbohydrates Sections
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More Complex Carbohydrates
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