Biochemistry Online: An Approach Based on Chemical Logic

Biochemistry Online


B: Lipids in Water



Learning Goals/Objectives for Chapter 1B:  After class and this reading, students will be able to

  • draw graphs/diagrams to explain the similarities in behavior when salts, organic solvents, and lipids are added to water
  • state the differences between single and double chain amphiphiles, the structures they form in water (micelles and bilayers), and the intermolecular forces involved in their interactions with self and water
  • explain the changes in interactions of amphiphiles with water and self in the formation of liposomes
  • explain the uses  and advantages disadvantages of gel filtration and dialysis
  • 1B4.  General Links and References

    Brasaemle, D. and Wolins, N. Packing of Fat: An Evolving Model of Lipid Droplet Assembly and Expansion.   J. Biol Chem.  287, 2273 (2012)

    Farese, R. & Walther, T. Lipid Droplets Finally Get a Little RESPECT.  Cell. 139 pg 855 (2009) Martinez et al. Self-Assembling Amphiphilic Siderophores from Marine Bacteria.  Science. 287. pg 1245 (2000)

     Beckman et al. Designed to Dissolve.  (Designing CO2-philic materials for use with supercritical CO2)  Nature. 405, pg 129, 165 (2000) Korlach et al. Characterization of lipid bilayer phases by confocal microscopy and fluorescence correlation spectroscopy PNAS, 96, pg 8461 (1999)

    Zhou et al. Spherical Bilayer Vesicles of Fullerene-Based Surfactants in Water: A Laser Light Scattering Study.  Science. 291,  pg. 1944 (2001). 


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