Biochemistry Online: An Approach Based on Chemical Logic

Biochemistry Online

The Origin of Life


N.  Links and References

B. Subtilis: 271

The Origins of Life on Earth, Leslie Orgel

Orgel: Scientific Am Article

Interview with Stanley Miller

Venter synthesizes whole bacterial genome |

Exploring Life's Origins

Ted Talk: Protocells


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  2. Morowitz, H. et al. Ligand Field Theory and the Origin of Life as an Emergent Feature of the Periodic Table of Elements.  Biol Bull. 219, 1-6 (2010)

  3. Pinheiro, V. et al. Synthetic genetic polymers capable of heredity and evolution.  Science 336, 341 (2012)

  4. Lane, N et al. How did LUCA make a living? Chemisomosis in the origin of life. BioEssays 9999, 1-10 (2010) DOI 10.1002/bies.200900131

  5. Russell, M, and Martin, W. The rocky roots of the AcetylCoA pathway. TIBS, 29, pg 358 (2004)

  6. Shock EL, McCollom TM, Schulte MD. The emergence of metabolism from within hydrothermal systems. In Wiegel J, Adams MWW. ed; Thermophiles: The Keys to Molecular Evolution and the Origin of Life. London: Taylor & Francis. p 59�76.a998)

  7. Powner, M et al. Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions. Nature 459, 239-242 (14 May 2009) | doi:10.1038/nature08013;

  8. Chen, I. The Emergence of Cells During the Origin of Life.  Science 314, 1558 (2006)

  9. Chen, I., Roberts, R. & Szostak, J. The emergence of competition between model protocells. Science 305, 1474 (2004)

  10. Chen, I and Szostak, J.  Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles. PNAS, 101, 7965 (2004)

  11. Leman, L, Orgel, L, and Ghadiri, M. Carbonyl Sulfide-Mediated Prebiotic Formation of Peptides.  Science 306, 283 (2004)

  12. Brenner, S. Understanding Nucleic Acids Using Synthetic Chemistry. Acct. Chem. Research  37, 784 (2004)

  13. Hanczyc, J., Fukikawa, S. and Szostak, J. Experimental Models of Primitive Cellular Compartments: Encapsulation, Growth, and Division. Science 302, 618 (2003)

  14. Kobayashi, K. et al. Essential Bacillus subtilis genes.  PNAS 100, 4678 (2003)

  15. Rasmussen, S. et al. Bridging Nonliving and Living Matter.  Artificial Life 9: 269 (2003)

  16. Krishna N. Ganesh and Peter E. Nielsen. Peptide Nucleic Acids: Analogs and Derivatives. Current Organic Chemistry.  4, 931 (2000)

  17. Saghatelian, A. , Yokobayashi Y, Soltani K, Ghadiri MR.  A chiroselective peptide replicator. Nature 409, 797 (2001). Nelson, K., Levy, M. & Miller, S. Peptide nucleic acids rather than RNA may have been the first genetic molecule. PNAS 97, 3868 (2000)

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  19. Ferris, J, & Ertem, G et al. Oligmerization of ribonucleotides on montmorillonite: reaction of the 5'-phosphorimidazolide of adenosine.   Science. 257, 1387 (1992)


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