Biochemistry Online: An Approach Based on Chemical Logic

CHAPTER 2 - PROTEIN STRUCTURE

BIOCHEMISTRY - DR. JAKUBOWSKI

Last Update: 02/27/16

Learning Goals/Objectives for Chapter 2A: After class and this reading, students will be able to

state the charge on amino acid side chains using the Henderson Hasselbach equation and the approximate charge by inspection at any given pH
draw mechanisms and identify products for the reaction of nucleophilic side chains Lys and Cys with common chemical modification agents and extend this understanding to reactions of His.
draw mechanisms for disulfide exchange reactions for sulfhydryls using them and oxidation numbers to explain redox reactions of cysteine/cystine.

The Amino Acid Repository from the Image Library of Biological Molecules. Contains a great data base of properties about amino acids.
Amino Acid Information form Rockefeller University.

References

Chin, J. et al. An expanded eukaryotic genetic code. Science. 301. pg 964 (2003)
Schultz, P. et al. JACS, last week January, 2003
A New Twist on Chirality (how homochirality in amino acids may have developed). Science. 292, pg 2021 (2001)

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Archived version of full Chapter 2A: Amino Acids