Biochemistry Online: An Approach Based on Chemical Logic

Biochemistry Online

CHAPTER 2 - PROTEIN STRUCTURE 

A:  AMINO ACIDS

BIOCHEMISTRY - DR. JAKUBOWSKI

Last Update:  02/27/16

Learning Goals/Objectives for Chapter 2A:  After class and this reading, students will be able to

  • state the charge on amino acid side chains using the Henderson Hasselbach equation and the approximate charge by inspection at any given pH
  • draw mechanisms and identify products for the reaction of nucleophilic side chains Lys and Cys with common chemical modification agents and extend this understanding to reactions of His.
  • draw mechanisms for disulfide exchange reactions for sulfhydryls using them and oxidation numbers to explain redox reactions of cysteine/cystine.

A6.  Reactions of Cysteine

Cysteine is a potent nucleophile, which is often linked to another Cys to form a covalent disulfide bond.

Figure:  CYSTEINE REACTIONS 1


Figure:  a quick review of sulfur redox chemistry


Figure: CYSTEINE REACTIONS 2

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