Biochemistry Online: An Approach Based on Chemical Logic

CHAPTER 2 - PROTEIN STRUCTURE

BIOCHEMISTRY - DR. JAKUBOWSKI

Last Update: 3/9/16

Learning Goals/Objectives for Chapter 2G: After class and this reading, students will be able to:

find web based proteomics protein to analyze protein sequences and structures
describe the basis for methods used to predict the secondary structure and hydrophobic structures of proteins
analyze secondary structure and hydropathy plots from web-based proteomics programs.
describe differences between integral and peripheral membranes proteins, and how each could be purified.
explain how hydropathy and secondary structure plots can be used to predict membrane spanning sequences of proteins
describe in general the theoretical and empirically based methods to predict protein tertiary structure from a primary sequence
describe possible early intermediates in protein folding as determined by theoretical methods

Bradley, P. et al. Toward high-resolution de novo structure prediction for small proteins. Science. 309, 1868 (2005)
Boyle J. A. Bioinformatics in Undergraduate Education. Biochemistry and Molecular Biology Education. 32, 236 (2004)
Feig, A. L., & Jabri, E. . Incorporation of Bioinformatics Exercises into the Undergraduate Biochemistry. Biochemistry and Molecular Biology Education. 30, 224 (2002)
Mayor et al. The complete folding pathway of a protein from nanoseconds to microseconds. Nature 421, pg 863 (2003)
Zhou and Karplus. Interpreting the folding kinetics of helical proteins. Nature 401, pg 400(1999)

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