Biochemistry Online: An Approach Based on Chemical Logic

Biochemistry Online

CHAPTER 9 - METABOLIC AND SIGNAL TRANSDUCTION

A.  ACTIVE TRANSPORT 

BIOCHEMISTRY - DR. JAKUBOWSKI

 04/16/16

Learning Goals/Objectives for Chapter 9A:
After class and this reading, students will be able to

  • list energy sources used to move ions/molecules from low to high concentrations across a concentration gradient;
  • explain how ATP is used to drive the thermodynamically uphill movement of Na and K ions by the Na?K ATPase

A3.  Transport of Sugars

Lactose - Lactose can be transported into E. Coli against a concentration gradient using galactoside permease, one of the proteins encoded by the lac operon. This protein uses a proton-motive force to pump lactose into the cell. The proton gradient is created by an electron transport complex in the membrane which is inhibited by cyanide, reminiscent of the cytochrome C oxidase complex in oxphos.

Figure:  Lactose Transport

Glucose - Glucose can be transported into brush border cells lining the small intestine powered by a sodium-motive symport transporter.

Figure:  Glucose Transport

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