Biochemistry Online: An Approach Based on Chemical Logic

CHAPTER 9 - METABOLIC AND SIGNAL TRANSDUCTION

BIOCHEMISTRY - DR. JAKUBOWSKI

04/16/16

Learning Goals/Objectives for Chapter 9A:
After class and this reading, students will be able to

list energy sources used to move ions/molecules from low to high concentrations across a concentration gradient;
explain how ATP is used to drive the thermodynamically uphill movement of Na and K ions by the Na?K ATPase

Darland-Ransom, M. et al. Role of C. elegans TAT-1 Protein in Maintaining Plasma Membrane Phosphatidylserine Asymmetry. Science 320: 528 (2008)
The xyz of ABC Transporters (require ATP, overexpression lead to resistance to antibiotics, chemotherapy, etc). Science. 293, pg 1782 (2001)
Bacteriorhodopsin- the movie. Nature. 406, pg 569, 645, 649, 653 (2000)
Toyoshima et al. Structure of sacroplasmic reticulum Ca pump. Nature. 405, pg 633, 647 (2000)
Luecke, H. et al. Structural Changes in Bacteriorhodopsin During Ion Transport at 2 Angstrom Resolution, Science 286, 255 (1999).

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Archived version of full Chapter 9A: Active Transport