Some enzymes regulated by cAMP-dependent phosphorylation by PKA
Enzyme | Pathway |
Glycogen Synthase | glycogen synthesis |
Phosphorylase Kinase | glycogen breakdown |
Pyruvate Kinase | Glycolysis |
Pyruvate Dehydrogensae | Pyruvate to acetyl-CoA |
Hormone-sensitive Lipase | Triacylglyeride breakdown |
Tyrosine Hydroxylase | Synthesis of DOPA, dopamine, norepinephrine |
Histone H1 | Nucleosome formation with DNA |
Histone H2B | Nucleosome formation with DNA |
Protein phosphatase 1 Inhibitor 1 | Regulation of protein dephosphorylation |
CREB | cAMP regulation of gene expression |
PKA cosensus sequence | XR(R/K)X(S/T)B (B = hydrophobic amino acid) |