Reactivity in Chemistry
Carbonyl Addition
CO26.
Additional Problems
Problem
CO26.1.
Synthesize the following compounds
starting from acetone.
Problem CO26.2.
Researchers are investigating
cyclohexenone derivatives as potential inhibitors for esterases. Below is
a scheme for the synthesis of several of these derivatives. Fill in the
boxes with the appropriate intermediates or reagents.
Problem CO26.3.
Fill in the product or reagent
for each of the following transformations. Remember there is always an acidic
workup assumed.
Problem CO26.4.
Fill in the blanks in the
following synthesis. Includes addition to carbonyls (anionic
nucleophiles).
Problem CO26.5.
Fill in the blanks in the following synthesis.
Includes addition of nucleophiles to carbonyls (anionic nucleophiles, enolates,
ylides).
Problem CO26.6.
Fill in the blanks in the
following synthesis. Includes addition of nucleophiles to carbonyls
(anionic nucleophiles, enolates).
Problem CO26.7.
Fill in the blanks in the
following synthesis. Includes addition of nucleophiles to carbonyls
(anionic nucleophiles, enolates, ylides).
Problem CO26.8.
Fill in the blanks in the
following synthesis. Includes addition of nucleophiles to carbonyls
(anionic nucleophiles, enolates, conjugate additions, carboxyloid
substitutions).
Problem CO26.9.
Fill in the blanks in the
following synthesis. Includes addition of nucleophiles to carbonyls
(anionic nucleophiles, enolates, conjugate addition).
This site was written by Chris P. Schaller, Ph.D., College of Saint Benedict / Saint John's
University (retired) with other authors as noted on individual pages. It is freely
available for educational use.
Structure & Reactivity in Organic, Biological and
Inorganic Chemistry by
Chris Schaller is licensed under a
Creative
Commons Attribution-NonCommercial 3.0 Unported License.
Send corrections to cschaller@csbsju.edu
This material is based upon work supported by the National Science Foundation
under Grant No. 1043566.
Any opinions, findings, and conclusions or recommendations expressed in this
material are those of the author(s) and do not necessarily reflect the views of
the National Science Foundation.
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