Reactivity in Chemistry

Substitution at Carboxyloids

CX12.  Additional Problems

Problem CX12.1.

FIll in the blanks in the following syntheses.

Problem CX12.2.

Fill in the blanks in the following synthesis involving anionic nucleophilic addition to carbonyl and nucleophilic substitution at carboxyl.

Problem CX12.3.

Fill in the blanks in the following synthesis involving anionic nucleophilic addition to carbonyl and nucleophilic substitution at carboxyl.

Problem CX12.4.

Fill in the blanks in the following synthesis involving anionic nucleophilic addition to carbonyl and nucleophilic substitution at carboxyl  (including Wittig and aldol reactions).

 

Problem CX12.5.

 Fill in the blanks in the following synthesis involving nucleophilic substitution at carboxyl.

 

Problem CX12.6.

Fill in the blanks in the following synthesis involving anionic nucleophilic addition to carbonyl , nucleophilic substitution at carboxyl and conjugate addition .

 

Problem CX12.7.

Fill in the blanks in the following synthesis involving anionic nucleophilic addition to carbonyl, conjugate addition  and nucleophilic substitution at carboxyl.

Problem CX12.8.

Fill in the blanks in the following synthesis involving anionic nucleophilic addition to carbonylnucleophilic substitution at carboxyl and neutral nucleophilic addition to carbonyl.

 

Problem CX12.9.

Fill in the blanks in the following synthesis involving anionic nucleophilic addition to carbonyl/em>, conjugate addition, nucleophilic substitution at carboxyl and transition metal-catalysed coupling.

 

Problem CX12.10.

Fill in the blanks in the following synthesis involving anionic nucleophilic addition to carbonyl, conjugate addition, nucleophilic substitution at carboxyl and transition metal-catalysed coupling.

 

Problem CX12.11.

Fill in the blanks in the following synthesis involving anionic nucleophilic addition to carbonyl, conjugate addition, nucleophilic substitution at carboxyl, transition metal-catalysed coupling and neutral nucleophilic addition to carbonyl.

 

Problem CX12.12.

Fill in the blanks in the following synthesis involving anionic nucleophilic addition to carbonyl, conjugate addition, nucleophilic substitution at carboxyl, transition metal-catalysed coupling and neutral nucleophilic addition to carbonyl.

 

Problem CX12.13.

Fill in the blanks in the following synthesis involving anionic nucleophilic addition to carbonyl, conjugate addition, nucleophilic substitution at carboxyl, transition metal-catalysed coupling and neutral nucleophilic addition to carbonyl.

 

 

 

This site is written and maintained by Chris P. Schaller, Ph.D., College of Saint Benedict / Saint John's University (with contributions from other authors as noted).  It is freely available for educational use.

Send corrections to cschaller@csbsju.edu

This material is based upon work supported by the National Science Foundation under Grant No. 1043566.

Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.

 

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