Reactivity in Chemistry

Substitution at Carboxyloids

with problems contributed by Kate Graham

Get familiar with carboxyloid functional groups here.

CX1.  Introduction to Carboxyloids (Carboxylic Acid Derivatives)

CX2.  General Reactivity Patterns

CX3.  Comparative Energies: The Ski Hill

CX4.  Interconversion: Going Downhill

CX4b.  Bringing All The Steps Together: Ester and Amide Hydrolysis

CX5.  Getting Towed Uphill

CX6.  Semi-Anionic Nucleophiles

CX7.  Enolates:  Claisen Condensation

CX7b. Enolates:  Decarboxylation

CX8.  Condensation Polymers

CX8b.  Ring-Opening Trans-Esterification Polymerization

CX9.   Peptides and Proteins:  Laboratory Synthesis

CX10.  Protein Modifications

CX11.  Additional Problems

CX12.  Solutions For Selected Problems

 

 

 

This site was written by Chris P. Schaller, Ph.D., College of Saint Benedict / Saint John's University (retired) with other authors as noted on individual pages.  It is freely available for educational use.

Creative Commons License
Structure & Reactivity in Organic, Biological and Inorganic Chemistry by Chris Schaller is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License

Send corrections to cschaller@csbsju.edu

 

This material is based upon work supported by the National Science Foundation under Grant No. 1043566.

Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.

 

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