P-Selectin:EGF Domains
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I. Introduction
During inflammation, leukocytes
tether and roll on the walls of vessels where they are
become active. E-, L- and P-selectin proteins are the primary
units responsible for the tethering and rolling of these leukocytes.
P-selectin has an N-terminal lectin domain
followed by a EGF domain and 9 consensus repeat (CR) domains.
It binds to the P-selectin glycoprotein
ligand-1(PSGL-1), a homodimeric protein
of molecular weight 240K, expressed on leukocytes, in part through
thesialyl-Lewisx(SLEX) CHO on
the ligand. The interaction between P-selectin and
PSGL-1 mediates the
The following is a series of images of the crystalline structure of
the lectin:EGF domain complexed to
For more information see
Biochemistry Online: Chapter
3B - Complex Carbohydrates/Glycans and Glycoconjugate
II. General Structure
Wireframe
Backbone
Backbone and sidechainse
Backbone, sidechains and CHO
Cartoon and Wireframe
Cartoon Wireframe and CHO
Dot surface and Wireframe