Human
β2-Adrenergic G Protein-Coupled
Receptor
Java version
HTML 5 version (does not require Java; downloads and moves
slowly)
I. Introduction
For more information see
Biochemistry Online: Chapter 9C - Signal Transduction - Kinases and Phosphatases
II. General Structure
Wire frame model of protein
Protein with
Cholesterol and
Palmitic acid ligands bound -
These
secure the protein as a dimer form in a plasma membrane and show
the membrane disposition of the protein.
Protein with bound ligand Carazolol, a high affinity
antagonist
Protein with
Proline residues -
proline induces kinks at conserved positions along the span
of the transmembrane segments which are thought to enable the
structural rearrangements required for activation of G protein
effectors
(The next surface displays are solid and require calculations
with some time delays)
solvent excluded molecular surface -(solid 1.4 A) - surface at
contact with sphere (molecular) - with bound
cholesterol and
palmitic acid
Map of Electrostatic potential from a .pqb and .jvxl map files
with wireframe rendering -
Displays non-polar
region (green) where the protein is embedded in a membrane,
and the binding site (red) is
negatively charged. (May have to refresh page in order to view
this.)
Carazolol binding site in yellow:
Ser204,
Tyr199, Ser203, Ser207, Phe193, Asp113, Trp109, Tyr316, Trp286,
Asn312, Phe289, Tyr308, Phe290, Asn293