Human β2-Adrenergic G Protein-Coupled Receptor

Java version

HTML 5 version (does not require Java; downloads and moves slowly)


I. Introduction

For more information see Biochemistry Online: Chapter 9C - Signal Transduction - Kinases and Phosphatases


II. General Structure

Wire frame model of protein
Protein with Cholesterol and Palmitic acid ligands bound - These secure the protein as a dimer form in a plasma membrane and show the membrane disposition of the protein.
Protein with bound ligand Carazolol, a high affinity antagonist
Protein with Proline residues - proline induces kinks at conserved positions along the span of the transmembrane segments which are thought to enable the structural rearrangements required for activation of G protein effectors

(The next surface displays are solid and require calculations with some time delays)

solvent excluded molecular surface -(solid 1.4 A) - surface at contact with sphere (molecular) - with bound cholesterol and palmitic acid
Map of Electrostatic potential from a .pqb and .jvxl map files with wireframe rendering - Displays non-polar region (green) where the protein is embedded in a membrane, and the binding site (red) is negatively charged. (May have to refresh page in order to view this.)
Carazolol binding site in yellow: Ser204, Tyr199, Ser203, Ser207, Phe193, Asp113, Trp109, Tyr316, Trp286, Asn312, Phe289, Tyr308, Phe290, Asn293