Dr. Henry Jakubowski
TENTATIVE CLASS SCHEDULE
| Day | Date | OLSG | Topic |
| 1 | 1/15 Tu | Introduction: Of bacteria, chimpanzees and human |
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| 2 | 1/17 Th | LIP | Intro. to Lipids: (Non)Saponafiable; Fatty acid, Phospholipids |
| 3 | 1/21 M | LIP | Quiz PC; Lipid
Aggregates-Micelles and Bilayers; IMF's; Lab Prep of liposome; (Rev Session Thermodynamics Btw 3 and 4) |
| 4 | 1/23 W | LIP | Lab Prep of Liposomes;
Dynamics of Bilayers: Lateral, Flip Flop Diffusion, Gel-Liquid Crystaline Phase Change ; (PL composition and Tm discussed in lab) |
| 5 | 1/25 F | LIP | Dm;Δμo; partition coefficients; hydrophobic effect; ΔHo; ΔSo. Why bilayers and micelles; |
| 6 | 1/29 Tu | LIP PROT | Signal transduction;
fatty acid amide; amino acids; covalent modification; charge characteristics; |
| 7 | 1/31 Th | PROT | Cys modifications; Studying proteins: MW, concentration, specific AA, AA composition, N And C terminus ID, AA sequence, |
| 8 | 2/4 M | PROT | Quiz: pentapeptide; post-translational modification; Lab determine seconary, tertiary structure; phi/psi; secondary structure; supersecondary; proteins. PS 1: Lipids Due |
| 9 | 2/6 W | PROT | Protein Folding in vitro: worksheet exploring N<==>D, nature of N, D states; Keq,ΔGo, Anfinsen folding; Intermediates - Cys Trap; X-Pro isomerizatoin; Molten Globules; |
| 10 | 2/8 F B | PROT | Molten Globules; Protein Folding in vivo; Protein Folding/Stability: electrostatics, H Bonds, |
| 11 | 2/12 Tu | PROT | Protein Folding/Stability: Hydrophobic Effect; |
| 12 | 2/14 Th | PROT | Secondary, Tertiary Structure Prediction. Prions; What's New; |
| 13 | 2/18 M | CARB | Intro to Carbohydrates: Carbohydrate Jeopardy |
| 14 | 2/20 W | CARB | Membranes/Cell Wall; Introduction to Binding |
| 15 | 2/22 F | BIND | Fractional Saturation; Vary Kd; Vary Ligand; Experimental Det. Kd; |
| 16 | 3/6-3/8 | Test 1 | |
| 17 | 3/5 Tu | BIND | Temporal View of Kd; Intro. to Hb and Mb |
| 18 | 3/7 Th | BIND | Mathematical and Molecular Analysis of Hb binding curves: Hill; MWC; |
| 19 | 3/11 M | BIND | Transcriptional Control (Lab 4B3/31; 4/5) |
| 20 | 3/13 W (C) | BIND | Transcriptional Control; Drug Development; Gene Arrays |
| 21 | 3/15 F | TKIN | Facilitated Diffusion |
| 22 | 3/19 Tu | TKIN | Intro to Kinetics |
| 23 | 3/21 Th | TKIN | Enzyme Kinetics (Lab starts 4/10) |
| 24 | 3/25 M | TKIN | Inhibition of binding; Inhibition models for enzymes |
| 25 | 3/27 W | TKIN CAT | Multisubstrate enzymes; Regulatory enzymes; Introduction to Reactions |
| 26 | 4/3 W | CAT | Methods of enzyme-catalyzed reaction |
| 27 | 4/5 F | CAT | Methods of enzyme-catalyzed reaction; Enzyme reactions in organic solvents |
| 28 | 4/9 Tu | OXPH | Chemistry of Dioxygen; 4/17-4/20 Test 2; |
| 29 | 4/11 Th | OXPH | Biological Oxidation Reactions - Dehydrogenases, Mono and Dioxygenases, and Oxidases |
| 30 | 4/15 M |
OXPH | Mono and Dioxygenases, and Oxidases; Oxidation Rx's; ATP and Oxidative Phosphorylation Reactions |
| 31 | 4/17 W | OXPH | ATP and Oxidative Phosphorylation Reactions; Photosynthesis |
| 32 | 4/19 F | OXPH | Energy Transduction: Uses of ATP |
| 33 | 4/23 Tu | SIGT | Signal Transduction: Nerve Cells: Neural Chemistry |
| 34 | 4/25 Th | SIGT | Signal Transduction at Cell Membranes: Protein Kinases/Phosphatases |
| 35 | 4/29 M | SIGT | Apoptosis - Programmed Cell Death and Signal Transduction |
| 36 | 5/1 W | Review |