CHAPTER 2:  PROTEINS

Biochemistry Online: An Approach Based on Chemical Logic

08/08/2002

Proteins are covalent polymers of amino acids.   They are much more complicated than most lipids, since different proteins differ not only in the number of amino acids but also the sequence.  Compare this to the intermolecular aggregates of lipids which for the most part can be characterized as containing distinct hydrophobic and hydrophilic regions.  Remember, as with other biological polymers, proteins form from a covalent attachment of the amino end of one amino acid with the carboxy end of another, with release of water.  This later trait also occurs on formation of proteins and nucleic acids.

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During our study of proteins we will try to understand both the structure and function of the protein. We can gain understanding of proteins using both low and high resolution techniques, as illustrated in the figure below, which introduces how we will start our study of proteins.

Figure: Understanding the Properties of a Protein - Low to High Resolution

  1. The Structure and Property of Amino Acids
  2. Composition, Sequence and Conformational Analyis of Proteins;
  3. Understanding Protein Conformation
  4. Proteins Folding - In Vivo and In Vitro
  5. Laboratory Determination of DGo for Protein Folding/Unfolding
  6. Thermodynamics and IMF's in Protein Stability
  7. Prediction of Secondary and Hydrophobic Tertiary Structure
  8. Whats New in Protein Chemistry: Protein Aggregates - Not Just  Junk
  9. SUPPLEMENT: MOLECULAR MECHANICS AND DYNAMICS
  10. A web tutorial:  Principles of Protein Structure, Comparative Protein Modelling and Visualisation by Nicolas Guex and Manuel C. Peitsch. From ExPAYs

Recent References

  1. Self Assembly and Mineralization of Peptide-Amphiphile Nanofibers.  .  Science:  294, pg 1684 (2001)
  2. Baker et al. Protein Structure Prediction and Structural Genomics. Science.  294. pg 93 (2001)
  3. All in the Ubiquitin Family. Science. 289, pg 563 (2000)

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