Biochemistry Online: An Approach Based on Chemical Logic

Biochemistry Online




Last Updated: 03/14/13

Learning Goals/Objectives for Chapter 5E:  After class and this reading, students will be able to

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F7.  Links and References

MHC: T cell Receptor: Peptide Complexes

icon external linkanimation of protein processing and display of peptides by MHC proteins on cell surface

icon external linkPreparing for the next pandemic  NEJ May 5, 2005

icon external linkPossible mechanism for cytokine storm in influenza infection


Gao, H., Callaway, J. and P-Y-Ing, J. Inflammasomes:  mechanism of action, role in disease and therapeutics.  Nature Medicine. 21, 677 (2015)

Schmid-Burgk, J. et al.  A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation. J. Biol. Chem. 291, 103 (2016)

Yuan He et al. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux.  Nature 530, 354 (2016)

Eun-Kyeong Jo et al. Molecular mechanisms regulating NLRP3 inflammasome activation.  Cellular & Molecular Immunology (2016) 13, 148–159 Y

Yuan He et al. Mechanism and Regulation of NLRP3 Inflammasome Activation.  Trends in Biochemical Sciences, December 2016, Vol. 41, No. 12 © 2016

 Zehan He et al. Structural and biochemical basis for induced self-propagation of NLRC4.  Science 350, 399 (2015)

Liman Zhang et al. Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.  Science 350, 404 (2015)

Zhonghua Liu and Tsan Sam Xiao.  Assembling the wheel of death.  Science Science 350, 376 (2015)

Silvia Penuela et al. The biochemistry and function of pannexin channels.  Biochimica et Biophysica Acta 1828 (2013) 15–22




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Biochemistry Online by Henry Jakubowski is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.