CHAPTER 5 - BINDING

F:   IMMUNE SYSTEM RECOGNITION

BIOCHEMISTRY - DR. JAKUBOWSKI

Last Updated: 03/14/13

F7.  Links and References

MHC: T cell Receptor: Peptide Complexes

animation of protein processing and display of peptides by MHC proteins on cell surface

Preparing for the next pandemic  NEJ May 5, 2005

Possible mechanism for cytokine storm in influenza infection

References

Gao, H., Callaway, J. and P-Y-Ing, J. Inflammasomes:  mechanism of action, role in disease and therapeutics.  Nature Medicine. 21, 677 (2015)

Schmid-Burgk, J. et al.  A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation. J. Biol. Chem. 291, 103 (2016)

Yuan He et al. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux.  Nature 530, 354 (2016)

Eun-Kyeong Jo et al. Molecular mechanisms regulating NLRP3 inflammasome activation.  Cellular & Molecular Immunology (2016) 13, 148–159 Y

Yuan He et al. Mechanism and Regulation of NLRP3 Inflammasome Activation.  Trends in Biochemical Sciences, December 2016, Vol. 41, No. 12 http://dx.doi.org/10.1016/j.tibs.2016.09.002 © 2016

 Zehan He et al. Structural and biochemical basis for induced self-propagation of NLRC4.  Science 350, 399 (2015)

Liman Zhang et al. Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.  Science 350, 404 (2015)

Zhonghua Liu and Tsan Sam Xiao.  Assembling the wheel of death.  Science Science 350, 376 (2015)

Silvia Penuela et al. The biochemistry and function of pannexin channels.  Biochimica et Biophysica Acta 1828 (2013) 15–22

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