Questions
Fig 4 A: A variety of 1,4-Naphthoquinone derivatives were tested to see their effect on p300 activity in the presence and absence of NAC. One, lawsone, whose structure is given below, showed no inhibitory effects, as shown below. Give a likely chemical explanation for this observation.
Fig 4C. If they reacted with free thiols, then the naphthoquinone derivatives should have an effect on the concentration of free thiols in an in vitro assays. Results of one such assay are shown below.
Compare this graph with the proceeding one. What conclusion can you draw?
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