Calmodulin EF Hand
Helix - Loop - Helix
Java version
HTML 5 version (does not require Java; downloads and moves
slowly)
I. Introduction
Here is the structure of amino
acids 118-148 of human calmodulin. This proteins binds calcium and
modulates many intracelluar processes - it is a calcium
modulatory protein (or calmodulin). Shown is a
helix-loop-helix supersecondary structure motiff.
Calcium (shown
in spacefill rendering) is bound
in the loop and is coordinated to Glu side chains protruding in from
the loop
For more information see
Biochemistry Online: Chapter
2C - Understanding Protein Conformation
II. General Structure
Wireframe
Backbone
Backbone and side chains
Ca
2+ and side
chain
interactions
- notice the carboxyl Os interacting with the calcium
Cartoon showing hydrogen bonds
Cartoon and Wireframe
Dot surface and Wireframe