Glyceraldehyde-3-phosphate dehydrogenase
Active site nucleophile Cys149Ser Mutant
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For more information see
Biochemistry Online: Chapter 7C - Cofactors and Electron Pushing - Sources and
Sinks
II. General Structure
Wireframe
Cartoon showing 4 monomers
Individual subunits with bound
NAD+ (blue) and
glyceraldehyde-3-phosphate
(green)
Active Site:NAD+ in
Blue, Protein Wireframe; Cartoon Domains: NAD Binding Domain in
Yellow, Substrate Binding Domain in
Red
NAD+
(wireframe) Coordination
Motif: Asp 32;
Arg 72;
Gly 97;
Ser 119, 149;
(His 176;
Tyr 178; Asn 313
Spacefill
visualization of bound substrates
Protein
(gray),
Binding Site Region (red),
NAD+
(blue);
Glyceraldehyde3-P (green)