Low Molecular Weight Protein Tyrosine Phosphatase
Java version
HTML 5 version (does not require Java;
downloads and moves slowly)
I. Introduction
Proteins are polymers that are constructed of 20 different amino acid monomers linked together to form a large chain.
The chain then folds on itself in 3D space to a specific, unique structure with binding pockets for other molecules. This
tutorial will show one of the 148 amino acids, Phenylalanine 10 (Phe 10 in the folded structure.The atoms in Phe consistmostly of C and H, so it is nonpolar and contains few slight postive
and negative. On folding does Phe 10 bury itself in the interior of the densely packed protein or is in on the surface,
where the nonpolar atoms are exposed to water? See below for the answer
For more information see
Biochemistry Online: Chapter 2C - Understanding Protein Conformation
II. General Structure
Wireframe
Backbone
Cartoon
Cartoon and Wireframe
Phe10 - Spacefill
Zoom in on Phe 10 - Spacefill
The amino acids around Phe 10
The nonpolar amino acids (Val 8, Leu 9, Val 11, Cys 12,Ala 19, Ala 22, Phe 26, Ile 41, Leu 89, Leu 116, Cys 149)around Phe 10