Human Serum Albumin
(HSA)
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I. Introduction
HSA is a plasma protein responsible for the transport of fatty acids throughout the body.
There are a total of 11 distinct fatty acid binding sites.
For more information see
Biochemistry Online: Chapter 1B - Lipids in Water
II. General Structure
Wireframe
Backbone
Backbone and sidechains
Cartoon
, Hbonds and Wireframe
Cartoon and Wireframe Showing Disulfide Bridges
Cartoon Alpha Helices
Bound with Steric Acid
Color Coded Secondary Structures Bound With Stearic Acid
HSA is a 585 amino acid residue monomer, with a
secondary structure broken into 3 domains, with A and B sub-domains in each domain. Each domain and sub-domain have been color
coded as follows: I, red;
II, green; III, blue. The sub-domains A
and B are coded light and dark shades respectively.
Domains IIIA and IIIB with stearic acid bound in binding site 5.
Amino residuesTyr401 and Lys525 are in wireframe to show the
interaction with head group of fatty-acid.