Lactose Permease complexed with thiodigalactoside

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I. Introduction

Lactose Permease is produced by the lac Y gene, and transports the -galactoside into E. coli. This protein has 12 α-helices which span the cell membrane. The ligand, thiodigalactoside (TDG), is an analog of lactose, and is shown in spacefill in the selections below.

For more information see Biochemistry Online: Chapter 6A - Passive and Facilitated Diffusion

II. General Structure

Backbone and sidechains
Cartoon showing hydrogen bonds
Cartoon and Wireframe