MC4-R
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Homology Models of the Melanocortin 4 Receptor
For more information see
Chapter 9 C:
Signal Transduction at Cell Membranes: Protein Kinases/Phosphatases
5 Different homology models of the MC-4R receptor, a GPCR, are shown below.
Model 1:
Wire Frame
Backbone and sidechains
Cartoon
Cartoon, NDP-MSH Contacts?
Hydrophobic: W258,F261,H264 (Gray spacefill);Ionic: E100, D122, D126 (Red Spacefill)
Cartoon, NDP-MSH Contacts?
Hydrophobic(Gray spacefill) and
Ionic(Red Spacefill) and
ANDI F/Y for mutations (Green Spacefill)
Cartoon, NDP-MSH Contacts? (
Gray,
Red Spacefill);
ANDI F/Y for mutations (Green Spacefill) and
Obesity Nterm Conserved (Blue)
Model 2:
Wire Frame
Backbone and sidechains
Cartoon
Cartoon, Spacefill Tyrptophans, and N term Met (red spacefill)
Model 3:
Wire Frame
Backbone and sidechains
Cartoon
Cartoon, Spacefill Tyrptophans, and N term Met (red spacefill)
Model 4:
Wire Frame
Backbone and sidechains
Cartoon
Cartoon, Spacefill Tyrptophans, and N term Met (red spacefill)
Model 5:
Wire Frame
Backbone and sidechains
Cartoon
Cartoon, Spacefill Tyrptophans, and N term Met (red spacefill)