MC4-R

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Homology Models of the Melanocortin 4 Receptor

For more information see Chapter 9 C: Signal Transduction at Cell Membranes: Protein Kinases/Phosphatases


5 Different homology models of the MC-4R receptor, a GPCR, are shown below.

Model 1:

Wire Frame
Backbone and sidechains
Cartoon
Cartoon, NDP-MSH Contacts? Hydrophobic: W258,F261,H264 (Gray spacefill);Ionic: E100, D122, D126 (Red Spacefill)
Cartoon, NDP-MSH Contacts? Hydrophobic(Gray spacefill) and Ionic(Red Spacefill) and ANDI F/Y for mutations (Green Spacefill)
Cartoon, NDP-MSH Contacts? (Gray,Red Spacefill); ANDI F/Y for mutations (Green Spacefill) and Obesity Nterm Conserved (Blue)

Model 2:

Wire Frame
Backbone and sidechains
Cartoon
Cartoon, Spacefill Tyrptophans, and N term Met (red spacefill)

Model 3:

Wire Frame
Backbone and sidechains
Cartoon
Cartoon, Spacefill Tyrptophans, and N term Met (red spacefill)

Model 4:

Wire Frame
Backbone and sidechains
Cartoon
Cartoon, Spacefill Tyrptophans, and N term Met (red spacefill)

Model 5:

Wire Frame
Backbone and sidechains
Cartoon
Cartoon, Spacefill Tyrptophans, and N term Met (red spacefill)