Structural basis of dsRNA processing by Dicer
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For more information see
Biochemistry Online: Chapter 5D - Binding and the Control of Gene
II. General Structure
Note: This tetrameric protein
structure does not
Note the GLU,
ASP interaction with the
and the internal heterodimer formed by the two RNaselll located in
the head of each subunit.
Individual dicer subunits of the tetramer will appear with time.
Wait until all show.
Note the centralized positive charge density (blue) in
the PAZ regions used for binding of dsRNA
acids forming the 3' overhang-binding pockets
Located in the PAZ domain of the sub-units the highlighted
Tyrosine, Phenylalanine, and Histidine play
and important role in binding of dsRNA.