**Reactivity in Chemistry**

**Substitution at Carboxyloids **

**CX12. Additional Problems**

Problem CX12.1.

FIll in the blanks in the following syntheses.

Problem CX12.2.

Fill in the blanks in the following synthesis involving
*anionic nucleophilic addition to carbonyl *and *nucleophilic
substitution at carboxyl.*

Problem CX12.3.

Fill in the blanks in the following synthesis involving*
anionic nucleophilic addition to carbonyl *and *nucleophilic substitution
at carboxyl.*

Problem CX12.4.

Fill in the blanks in the following synthesis involving*
anionic nucleophilic addition to carbonyl *and *nucleophilic substitution
at carboxyl *(including Wittig and aldol reactions).

Problem CX12.5.

Fill in the blanks in the following synthesis involving *nucleophilic substitution
at carboxyl.*

Problem CX12.6.

Fill in the blanks in the following synthesis involving*
anionic nucleophilic addition to carbonyl *, *nucleophilic substitution
at carboxyl* and * conjugate addition *.

Problem CX12.7.

Fill in the blanks in the following synthesis involving
*anionic nucleophilic addition to carbonyl*, *conjugate addition*
and *nucleophilic substitution at carboxyl.*

Problem CX12.8.

Fill in the blanks in the following synthesis involving
*anionic nucleophilic addition to carbonyl*, *nucleophilic
substitution at carboxyl* and *neutral nucleophilic addition to carbonyl.*

Problem CX12.9.

Fill in the blanks in the following synthesis involving
*anionic nucleophilic addition to carbonyl/em>, conjugate addition,
nucleophilic substitution at carboxyl and transition
metal-catalysed coupling.*

Problem CX12.10.

Fill in the blanks in the following synthesis involving*
anionic nucleophilic addition to carbonyl, conjugate addition,
nucleophilic substitution at carboxyl *and

Problem CX12.11.

Fill in the blanks in the following synthesis involving*
anionic nucleophilic addition to carbonyl, conjugate addition,
nucleophilic substitution at carboxyl, transition metal-catalysed coupling
*and

Problem CX12.12.

Fill in the blanks in the following synthesis involving*
anionic nucleophilic addition to carbonyl, conjugate addition,
nucleophilic substitution at carboxyl, transition metal-catalysed coupling
*and

Problem CX12.13.

Fill in the blanks in the following synthesis involving
*anionic nucleophilic addition to carbonyl, conjugate addition,
nucleophilic substitution at carboxyl, transition metal-catalysed coupling
*and

This site is written and maintained by Chris P. Schaller, Ph.D., College of Saint Benedict / Saint John's University (with contributions from other authors as noted). It is freely available for educational use.

Send corrections to cschaller@csbsju.edu

This material is based upon work supported by the National Science Foundation under Grant No. 1043566.

Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.

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