Reactivity in Chemistry
Substitution at Carboxyloids
with problems contributed by Kate Graham
Get familiar with carboxyloid functional groups here.
CX1. Introduction to Carboxyloids (Carboxylic Acid Derivatives)
CX2. General Reactivity Patterns
CX3. Comparative Energies: The Ski Hill
CX4. Interconversion: Going Downhill
CX4b. Bringing All The Steps Together: Ester and Amide Hydrolysis
CX5. Getting Towed Uphill
CX6. Semi-Anionic Nucleophiles
CX7. Enolates: Claisen Condensation
CX7b. Enolates: Decarboxylation
CX8b. Ring-Opening Trans-Esterification Polymerization
CX9. Peptides and Proteins: Laboratory Synthesis
CX10. Protein Modifications
CX11. Additional Problems
CX12. Solutions For Selected Problems
This site was written by Chris P. Schaller, Ph.D., College of Saint Benedict / Saint John's University (retired) with other authors as noted on individual pages. It is freely available for educational use.
Structure & Reactivity in Organic, Biological and
Inorganic Chemistry by
Chris Schaller is licensed under a
Creative
Commons Attribution-NonCommercial 3.0 Unported License.
Send corrections to cschaller@csbsju.edu
This material is based upon work supported by the National Science Foundation under Grant No. 1043566.
Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.
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