Biochemistry Online: An Approach Based on Chemical Logic

Biochemistry Online

CHAPTER 5 - BINDING

E:   MODERN METHODS IN DRUG DEVELOPMENT

BIOCHEMISTRY - DR. JAKUBOWSKI

Last Updated: 03/31/16

Learning Goals/Objectives for Chapter 5E:  After class and this reading, students will be able to

  • describe the basis for the following methods used to design drugs:
    1. combinatorial drug development
    2. computer-aided design
    3. in situ click chemistry
  • describe drugs that target specific
    1. proteins
    2. DNA
    3. RNA
  • describe the benefit of drugs that
    1. are mutivalent
    2. perturb equilibrium

The difficulty lies, not in the new ideas, but in escaping the old ones, which ramify, for those brought up as most of us have been, into every corner of our minds. - John Maynard Keynes

E1.  Introduction to Drug Development

E2.  Combinatorial Drug Development

E3.  Computer Design of Drugs

E4.  In Situ Click Chemistry in Drug Synthesis

E5.  DNA Binding Drugs

E6.  DNA Binding and Genomic Analyses

E7.  RNA Binding Drugs

E8.  Multivalent Inhibitors

E9.  Targeted Delivery of Drugs to Tumors

E10.  Diseases of Protein Misfolding and Aggregation

E11.  Links and References

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