Biochemistry Online: An Approach Based on Chemical Logic

Biochemistry Online

 CHAPTER 7 - CATALYSIS

B:  MECHANISMS OF ENZYME CATALYSIS

BIOCHEMISTRY - DR. JAKUBOWSKI

 004/12/16

Learning Goals/Objectives for Chapter 7B:  After class and this reading, students will be able to

  • identify the types of catalysis used in enzyme-catalyzed reactions given a detailed mechanism;
  • interpret kinetic experiments experiments varying substrate, inhibitors, pH, ion strength, and amino acid side chains (through chemical modification or site-specific mutagenesis) to better understand the catalytic mechanisms utilized in enzyme-catalyzed reactions;
  • identify potential rate limiting steps in enzyme catalyzed reaction mechanisms and simplify kinetic equations based on them;
  • generally describe the diversity, the critical active site residues and the biological activities of proteases;
  • describe the structure/function of the proteasome.

B1.  Carboxypeptidase

B2.  Lysozyme

B3.  Chymotrypsin

B4.  Proteases Mechanisms

B5.  Protease Activation and the Proteasome

B6.  Motion and Enzyme Catalysis

B7.  Quantum Mechanisms (TBD)

B8.  Links and References

Additions

B9.  CRISPR new 7/1/17

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