Biochemistry Online: An Approach Based on Chemical Logic

Biochemistry Online

CHAPTER 2 -  PROTEIN STRUCTURE

H:  PROTEIN AGGREGATES AND DISEASE

BIOCHEMISTRY - DR. JAKUBOWSKI

Last Update:  03/10/16

Learning Goals/Objectives for Chapter 2H:  After class and this reading, students will be able to

  • describe experimental evidence to show that protein misfolding and aggregation depends on the amino acid sequence and the environment in which folding occurs.
  • describe conditions in vitro that may promote aggregation and how these might be minimized in vivo
  • describe alternative conformations of prion proteins and relate them to a energy topology landscape
  • explain how prion diseases may be transmitted in the absence of genetic material

H1.  Protein Aggregation

H2.  Prions and Disease

H3.  Misfolding and Aggregation Summary

H4.  Recent Links and References

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