Skills to Develop

• define and give examples of general acid/base, electrostatic, nucleophilic (covalent), and intramolecular methods of catalysis of chemical reactions in the absence of enzymes;
• draw mechanisms showing transition states and intermediates in general acid/base and nucleophilic catalysis;
• explain the role of transition state stabilization and preferential binding of the transition state compared to the substrate for macromolecule-catalyzed chemical reactions