Biochemistry Online: An Approach Based on Chemical Logic

Biochemistry Online

CHAPTER 2 - PROTEIN STRUCTURE

G:  PREDICTING PROTEIN PROPERTIES FROM SEQUENCES

BIOCHEMISTRY - DR. JAKUBOWSKI

Last Update:  3/9/16

Learning Goals/Objectives for Chapter 2G:  After class and this reading, students will be able to:

  • find web based proteomics protein to analyze protein sequences and structures
  • describe the basis for methods used to predict the secondary structure and hydrophobic structures of proteins
  • analyze secondary structure and hydropathy plots from web-based proteomics programs.
  • describe differences between integral and peripheral membranes proteins, and how each could be purified.
  • explain how hydropathy and secondary structure plots can be used to predict membrane spanning sequences of proteins
  • describe in general the theoretical and empirically based methods to predict protein tertiary structure from a primary sequence
  • describe possible early intermediates in protein folding as determined by theoretical methods

G1.  Introduction to Bioinformatics, Computational Biology and Proteomics

G2.  Prediction of Secondary Structure

G3.  Prediction of Hydrophobicity

G4.  Prediction of Membrane Protein Structure

G5.  Prediction of Protein Tertiary Structure

G6.  Proteomics Problem Set 1

G7.  Proteomics Problem Set 2

G8.  General Links and References

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