Reactivity in Chemistry
Aliphatic Nucleophilic Substitution
with problems contributed by Kate Graham
NS1. Introduction to Aliphatic Nucleophilic Substitution
NS2. Possible Mechanisms of Nucleophilic Substitution
NS3. Rate Laws in Nucleophilic Substitution
NS4. Stereochemistry in Nucleophilic Substitution
NS5. Regiochemistry in Nucleophilic Substitution
NS6. Structural Effects in Nucleophilic Substitution
NS7. Solvent Effects in Nucleophilic Substitution
NS8. Nucleophilicity in Nucleophilic Substitution
NS9. Enolate Nucleophiles
NS10. Leaving Group Formation
NS11. Nucleophilic Addition to Strained Rings
NS12. Complications: Elimination Reactions
NS13. Regiochemistry in Elimination
NS14. Stereochemistry in Elimination
NS15. Factors Affecting Elimination Mechanism
NS16. Nucleophilic Substitution in Synthesis: Alcohols and Ethers
NS17. Nucleophilic Substitutions in Synthesis: Amines
NS18. Nucelophilic Substitution at Silicon
NS19. Extra Problems
NS20. Solutions for Selected Problems
This site was written by Chris P. Schaller, Ph.D., College of Saint Benedict / Saint John's University (retired) with other authors as noted). It is freely available for educational use.
Structure & Reactivity in Organic, Biological and Inorganic Chemistry by Chris Schaller is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License.
Send corrections to cschaller@csbsju.edu
This material is based upon work supported by the National Science Foundation under Grant No. 1043566.
Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.
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