Biochemistry Online: An Approach Based on Chemical Logic

Biochemistry Online





Learning Goals/Objectives for Chapter 8A:  After class and this reading, students will be able to

  • explain why oxidation reactions with ground state dioxygen have a high enough activation energy to make the reactions, although thermodynamically favored, kinetically slow
  • explain, using molecular orbital diagrams the difference between triplet and singlet dioxygen
  • using molecular orbital diagrams and Lewis structures, describe the chemical properties of the reduction products of dioxygen (superoxide, peroxide, and water)
  • explain the ways that biological systems use to enhance dioxygen activity and reduce the effects of reactive oxygen species (ROS) such as superoxide and peroxide
  •  write chemical reactions and mechanisms when appropriate for some reactions of triplet and singlet dioxygen, superoxide, peroxide and the hydroxy free radical
  • describe typical reaction of ROS with lipids, proteins, and nucleic acids and data to support the involvement of ROS in complex diseases and aging.
  • Briefly contrast the production and biological activities of ROS and reactive nitrogen intermediates (RNIs)

A1.  The History of Oxygen

A2.  The Properties of Dioxygen

A3.  The Reactions of Dioxygen and its Reduction Products

A4.  Oxidative Modification of Proteins

A5.  Oxidative Modification of Lipids

A6. Oxidative Modification of DNA

A7.  Biological Uses for Reactive Oxygen Species - ROS

A8.  Just Say NO - The Chemistry of Nitric Oxide

A9.  Antioxidants and Disease

A10.  Hypoxia

A11.  Links and References


Return to Biochemistry Online Table of Contents

Archived version of full Chapter 8A:  The Chemistry of Dioxygen


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Biochemistry Online by Henry Jakubowski is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.