Biochemistry Online: An Approach Based on Chemical Logic

Biochemistry Online

CHAPTER 9 - SIGNAL TRANSDUCTION

C:  SIGNALING PROTEINS  

BIOCHEMISTRY - DR. JAKUBOWSKI

04/16/16

Learning Goals/Objectives for Chapter 9C:
After class and this reading, students will be able to

  • define kinases and phosphatases and their role in signal transduction
  • define primary and secondary messengers and give specific examples of each
  • describe the role of G proteins in coupling ligand induced conformational changes in the bound receptor to activation of specific effector proteins such as adenylate cyclase and phospholipase
  • differentiate between kinases activated by second messengers and those activated by primary messengers (ligand-gated receptor Tyr kinases)
  • describe the structural characteristics of G protein coupled serpentine receptors and ligand gated receptor tyrosine kinases
  • draw a diagram showing the general features of kinases mediated signal transduction pathways that lead to activation of gene expression
  • differentiate between neuron responses mediated by neurotransmitters on binding gated receptor/ion channels compares to G-protein coupled receptors

Estonian Translation by Anna Galovich

C1.  Signaling Kinases

C2.  Protein Kinase A (PKA)

C3.  Protein Kinase C (PKC)  and Calmodulin-Dependent Kinase (CAM-PK)

C4.  Receptor Tyrosine Kinases (RTK)

C5.  Protein Kinase G (PKG)

C6.  G Protein Coupled Receptors (GPCR) and G proteins

C7.  GAPs and GEFs

C8.  Mitogen Activated Protein Kinases

C9.  Insulin Signaling - PI3K and Akt (Protein Kinase B)

C10.  AMP dependent protein kinase (AMPK)

C11.  Phosphatases

C12.  Signal Transduction and Reactive Oxygen Species

C13.  Metabotropic Neural Receptors

C14.  The Human Genome and Signal Transduction

C15.  Links and References

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