Biochemistry Online: An Approach Based on Chemical Logic

Biochemistry Online





Learning Goals/Objectives for Chapter 9B:
After class and this reading, students will be able to

  • describe how a transmembrane ion gradient and nongated/gated membrane ion channels specific for given ions can give rise to a transmembrane electric potential across membranes
  • given ion concentrations and the electrical potential across a membrane, predict likely changes in the membrane potential and ion concentrations on the opening of specific channnels;
  • use the Goldman equation to predict transmembrane electrical potentials;
  • state difference between the communication across the neuromuscular junction and a synapse between two neurons;
  • state the difference between nongated and gated ion channels;
  • describe different ways to open/close gated ion channels
  • describe the immediate changes in the muscle cells when acetylcholine is released into the neuromuscular junction
  • describe the roles of stimulatory neurotransmitter receptors, voltage-gated Na+and K+ channels and the Na/K-ATPase  in the activation of a neuron;
  • explain the mechanism for selectivity of K+ over the smaller Na+ ion in the K+ channel;
  • briefly explain how membrane protein channels can be gated open by changes in transmembrane potential;

B1.  Introduction to Neural Signaling

B2.  Transmembrane Potentials

B3.  Thermodynamics of Membrane Potential

B4.  Neurotransmitter Activation of Neurons

B5.  Proteins of the Neural Synapse

B6.  Ligand-Gated Acetylcholine Receptor of the Neuromuscular Junction

B7.  Voltage-Gated Sodium Channel

B8.  Voltage-Gated Potassium Channel

B9.  Excitatory  Neurotransmitters

B10.  Inhibitory Neurotransmitters

B11.  The Senses

B12.  Touch

B13.  Summary

B14.  Links and References


Return to Biochemistry Online Table of Contents

Archived version of full Chapter 9B:  Neural Signaling


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Biochemistry Online by Henry Jakubowski is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.