BIOCHEMISTRY - BCHM 322

COURSE SYLLABUS - SPRING 2013

Dr. Henry Jakubowski

05/05/2013

CLASS SCHEDULE AND ASSIGNMENTS

Day Date Date Read Before Class Do Before Class 
1 1/14 M A1  moodlelogo pretest assessment for bchm 322

  Sapling

  • Practice Assignment and Training Videos

  • Drawing Practice Activity
     

 

2 1/16 W A3

The cell from a chemist's eye

Chapt 1A - Lipid Struct.

Chapt 1B - Lip in Water

 

Pre-Class Questions  Lipid Structure: A. Lipid Structure - Question
Pre-Class Questions:    Lipid Structure: B. Lipids in Water - Question

Passport to class:  WB: a, b

Workbook (WB): 4,5

3 1/18 F  A5

Chapt 1C; Dynamics of membrane lipids;

Chapt 1D - Lipids in Water: Thermodynamics (to red line)
(Review Thermodynamics );Quiz PC

 

moodlelogoDriving Force:  THERMODYNAMICS - A REVIEW;

Molecular Mechanics and Dynamics:  SUPPLEMENT - MOLECULAR MECHANICS AND DYNAMICS

Pre-class Question:  1C - Lipid Dynamics
 WB: 6-11

4 1/22 T A1

 Chapt 1D - Lip Water: Thermodynamics

Chapt 1E - Why Micelles, Bilayers?

Chapt 1F - What's New?

moodlelogoLipids: Lipid Structure 1F:  LIPIDS AS BIOLOGICAL SIGNALS

Pre-Class Questions:    Lipid Structure D.  Lipids in Water - Thermodynamics - Question

5 1/24 R A3 Literature Learning Module:  Lipids This is a very difficult assignment.  Don't panic.  Do all of the questions, but your group will be assigned to present one of them in class.
Sapling Online Problems: Chapter 1- Lipids
(now due 1/25 at 11:00 am)

(X out of the browser if you wish to complete the Sapling assignment at a future date. Do not select the Exit icon within the Sapling assignment.) 
6 1/28 M A5

Chapt 2A - Prot/A. Acids

 

moodlelogoCharges on Amino Acids and Proteins: Protein Structure 2A: THE STRUCTURE AND PROPERTY OF AMINO ACID;

Buffers - Protein Structure 2A: THE STRUCTURE AND PROPERTY OF AMINO ACIDS

Amino Acids: Protein Structure 2A: THE STRUCTURE AND PROPERTY OF AMINO ACIDS


Pre-Class Questions:    Protein Structure:  Structure and Properties of Amino Acids - Question

7 1/30 W A1

Chapt 2B - Prot: Compo, Sequence, Conform.

moodlelogoProteins 1  Protein Structure 2B:  PROBING COMPOSITION, SEQUENCE, AND CONFORMATION
Sapling Online Problems: Chapter 2- Amino Acids
8 2/1 F A3

Chapt 2C - Prot: Conformation

moodlelogoProteins 2:  Protein Structure 2C: UNDERSTANDING PROTEIN CONFORMATION
9 2/5 T A5

Chapt 2D: Protein Folding/Stability

moodlelogoProtein Folding and Degradation:  Protein Structure 2D: PROTEIN FOLDING/STABILITY IN VIVO AND IN VITRO
Sapling Online Problems: Thermo Review
10 2/7 R B1

Chapt 2E: Lab Det ΔGo;

Chapt 2F: Thermo and IMF in Protein Fold/Stab.
Read up to RED LINE

Pre-Class Questions:  Determine the ΔGo of unfolding from actual data
Pre-Class Questions: 
  Protein Structure:  F. Thermodynamics and IMF - Electrostatics - Question

 

11 2/11 M B3

Chapt 2F: Thermo and IMF in Protein Fold/Stab. Finish

Pre-Class Questions:    Protein Structure:  F. Thermodynamics and IMF - H Bonds - Question
Pre-Class Questions:    Protein Structure: F. Thermodynamics and IMF - Hydrophobic Effect - Question
Passport to Class:  Changes in Protein Stability
12 2/13 W B5

Chapt 2F: New Studies on Protein Stability (from GREEN LINE to end)

Chapt 2G: Predict 20 and 3o struct;

Chapt 2 H: Prot. Aggregates

read
In class modeling
 
13 2/15 F B1

Literature Learning Module:  Proteins (DC)


Sapling Online Problems: Chapter 2 - Proteins
Problem Set 2C: Table Concept Map Due
14 2/19 T B3

Chapt 3A: Mono/Disacch.

Chapt 3B: Complex Oligos
 

Mini Test 1:  Lipids and Proteins T 2/19-R 2/21

moodlelogoCarbohydrates 1:  Chapter 3A:  MONOSACCHARIDES AND DISSACHARIDES

Carbohydrates 2:  Chapter 3B:  COMPLEX OLIGOSACCAHRIDES

Free Days, 21-22
15 2/25 M B5

Chapt 3C: Glycoproteins

Carbohydrate Jeopardy
 

 
16 2/27 W B1 Chapt 5A: Binding - Eq., Curves
Chapt 5B: Rev. Binding I
moodlelogoBinding:  Chapt 5B:  REVERSIBLE BINDING 2

Workbook: Pages 53-56

Sapling Online Problems: Chapter 3 - CHOs

17 3/1 F  B3

Chapt 5C: Mb, Hb and O2 to red line

moodlelogoMyoglobin and Hemoglobin: Chapt 5C:  A MODEL BINDING SYSTEM - MB, HB, AND DIOXYGEN

 


Pre-Class Questions:    Binding: C. Hemoglobin and Myoglobin - Question

18 3/5 T B5

Chapt 5C: Mb, Hb and O2

Review top central dogma (to red line)

5D: binding and gene expression

Read
19 3/7 R C1

Chapt 5D: binding and gene expression;

Chapt 5E: Drug Dev.

moodlelogoTranscription:  Chapt 5D:  BINDING AND THE CONTROL OF GENE TRANSCRIPTION

 

Pre-Class Questions:    Binding: D. Transcription - Question

20 3/11 M C3 Literature Learning Module:  Binding Extra Problem Sets: BINDING Due Electronically
Submit 1 per table group

 

Sapling Online Problems: Chapter 5 - Binding

21 3/13 W C5

Chapt 6A: Diffusion

Mini Test 2:  CHO and Binding Wed 3/13-Fri 3/15

moodlelogoFacilitated Diffusion:  Chapt 6A:  PASSIVE AND FACILITATED DIFFUSION

22 3/15 F C1

Chapt 6B: Rap. Eq/SS Enz. Kinetics

moodlelogoEnzyme Kinetics 1:  Chapt 6B:  Rapid Equilbrium and Steady State Kinetics

Enzyme Kinetics 2:  Chapt 6B:  Rapid Equilbrium and Steady State Kinetics

 

23 3/19 T C3

Chapt 6C: Models of Inhib.
Chapt 6D: More Complicated Models of Enz. Catalysis;

Video: Inhib and Complicated Enz


PROBLEM SET 4: THE CENTRAL DOGMA OF BIOLOGY
Sapling Online Problems: DNA, Genomics and Proteomics
24 3/21 R C5

Literature Learning Module:  Binding

Do it
Sapling Online Problems: Chapter 6 Transport/Kin
Spring Break/Easter Recess:  March 25-April 1
25 4/2 T C1

 

Chapt 7A: Catalysis

 
26 4/4 R C3

Chapt 7B: Mech. Enz. Catalyzed Rxs

moodlelogoEnzyme Mechanisms:  Chapt 7B:  MECHANISMS OF ENZYME-CATALYZED REACTIONS
Sapling Online Problems: Organic Chem Review
27 4/8 M C5

Chapt 7C: Cofactors and Electron Pushing

PROBLEM SET 5: ELECTRON PUSHING In Class: students draw mechanisms.
28 4/10 W D1

Chapt 7D: Enz. Cat. Rxs in Organic Solvent;

Chapt 7E:  Ribozymes

 
29

4/12 F D3

Literature Learning Module:  Catalysis

Do it
Sapling Online Problems: Chapter 7: Catalysis
30 4/16 T D5 Chapt 8A: Chem O2
Chapt 8B: Biol. Oxidation  Rxs
 
31 4/18 R D1 Chapt 8B: Biol. Oxidation  Rxs Pre-Class Questions: Using Reduction Potentials
Mini Test 3:  Diffusion, Enzyme Kinetics, Enzyme Mechanisms
Wed 4/17-Fri 4/19
32 4/22 M D3

Chapt 8C: ATP and OxPhos

moodlelogoGlycolysis: Chapt 8C:  ATP AND OXIDATIVE PHOSPHORYLATION REACTIONS

General Metabolism: Chapt 8C:  ATP AND OXIDATIVE PHOSPHORYLATION REACTIONS

 

SCHOLARSHIP AND CREATIVITY DAY:  4/24
33 4/25 R D5

Chapt 8C: ATP/Oxphos;

Chapt 8D: Photosynth.

Chapt 9A: Nrg - ATP

moodlelogoElectron Transport: Chapt 8C:  ATP AND OXIDATIVE PHOSPHORYLATION REACTIONS

ATP Synthesis:  Chapt 8C:  ATP AND OXIDATIVE PHOSPHORYLATION REACTIONS

Photosynthesis: Chapt 8D:  PHOTOSYNTHESIS: THE LIGHT REACTION

Pre-Class Questions:    Signal Transduction: 9A. ATP - Question

Sapling Online Problems: Chapter 8: Ox/Phos

34 4/29 M D1

Chapt 9B: Neurochem

moodlelogoActive Transport: Chapt 9A:  ENERGY TRANSDUCTION: USES OF ATP

Pre-Class Questions:     Signal Transduction: 9B. Nerves - Question

35 5/1 W D3

Chapt 9C: Kinases, Phosphatases
Web Survey

moodlelogoSignal Transduction: Chapt 9C:  SIGNAL TRANSDUCTION AT CELL MEMBRANES

 

36 5/3 F D5  
Eric Kandel: Nobel Lecture, 2000

or Influenza and the 1918 Pandemic

or Origin of Life

(Protocells)

or How do enzymes work?

or Understanding everything

Sapling Online Problems: Chapter 9 - Sig Trans
(due 5/6/13 5 PM - extended)


SALG Web Survey (complete by 5/6/13)
Instrument Number:
60667
Password:  cookie name no caps no spaces (from email)

(instructor) bu lao gou

CSB/SJU Student Web Surveys

  •  moodlelogoPostClass Assesment Quiz
  •  moodlelogoPost Class Assessment 2 Quiz

Complete above by 5/7/13, 5:00 pm

Final Exam: MAY 9, THURSDAY, 10:30 AM -12:30 PM - Computer Room - ASC 135 CSB