BIOCHEMISTRY ONLINE:

An Approach Based on the Logic of Chemistry

TABLE OF CONTENTS

DR. JAKUBOWSKI

Icon List in OLSG
	Pre-Class Question	Post responses to questions before class without
	Discus Question	Post responses to questions before class for all to see
	Chime Modeling	Ineractive molecular modeling displays of interesting molecules
	WebCT Quiz	Online Quizzes for your benefit which won't be graded
	XCel Spreadsheet	Spreadsheets which allow you to change variable and observe effects
	Java Applet	Interactive demonstrations to facilitate your learning of biological phenomena
	Check-In	Describe problems you have with the chapter material
	Online Literature	Full Text Online Articles from Leading Journals

Table of Contents

REVIEW:  THE CELL

1. Introduction to Lipid Structure
2. Lipid Structure and Stereochemistry
3. Lipids in Water : Structure
4. Dynamics of Bilayer Membranes
5. SUPPLEMENT: REVIEW SESSION ON THERMODYNAMICS
6. Lipids in Water: Thermodynamics
7. Why do Single Chain Amphiphiles form Micelles not Bilayers, and Double Chain Amphiphiles from Bilayers and not Micelles?
8. What's New in Lipid Biochemistry

1. The Structure and Property of Amino Acids
2. Composition, Sequence and Conformational Analyis of Proteins;
3. Understanding Protein Conformation
4. Proteins Folding - In Vivo and In Vitro
5. Laboratory Determination of ΔG^o for Protein Folding/Unfolding
6. Thermodynamics and IMF's in Protein Stability
7. Prediction of Secondary and Hydrophobic Tertiary Structure
8. What's New in Protein Chemistry: Protein Aggregates - Not Just  Junk
9. SUPPLEMENT: MOLECULAR MECHANICS AND DYNAMICS

1. Monosaccharides and Disssacharides
2. Complex Oligosaccharides
3. Jeopardy
4. Glycoproteins:  Biosynthesis and Function

1. The Structure of DNA
2. The Central Dogma of Biology
3. The Language of DNA
4. Proteomics
5. Human Genome Review

1. Reversible Binding I: Equations and Curves
2. Reversible Binding II: Experimental Binding Curves, Kd, and Error Analysis
3. A Model Binding System: Myoglobin. Hemoglobin, and Dioxygen
4. Binding and the Control of Gene Transcription:  
5. New Methods in Drug Development

1. Passive and Facilitated Diffusion
2. Steady State and Rapid Equilbirum Kinetics
3. Models of Enzyme Inhibition
4. More Complicated Enzymes

Chapter 7:  CATALYSIS

1. Methods of catalysis
2. Mechanisms of enzyme-catalyzed reactions
3. Enzyme catalyzed reactions in organic solvents
4. Ribozymes

1. The Chemistry of Dioxygen
2. Biological Oxidation Reactions - Dehydrogenases, Mono and Dioxygenases, and Oxidases
3. ATP and Oxidative Phosphorylation Reactions
4. Photosynthesis: The Light Reaction

1. Energy Transduction: Uses of ATP
2. Signal Transduction: Nerve Cells: Neural Chemistry
3. Signal Transduction at Cell Membranes: Protein Kinases/Phosphatases
4. Apoptosis - Programmed Cell Death  and Signal Transduction

• Searchable Biochemistry/Molecular Biology Books from the NCBI
• Useful Reference:  Molecular Cell Biology by Lodish, et. al.  (1999) Free Web Version.
• Common mistakes found in Biochemistry textbooks!
• Searchable Biochemistry concepts from Mathews, van Holde, and Ahern
• Web Companion for Biochemistry, 5th Edition, by Berg, Tymoczko and Stryer

Back to the CH 331 HOMEPAGE