BIOCHEMISTRY ONLINE:

An Approach Based on the Logic of Chemistry

TABLE OF CONTENTS

DR. JAKUBOWSKI

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Table of Contents

INTRODUCTION TO BIOCHEMISTRY

REVIEW:  THE CELL

Chapter 1:  LIPID STRUCTURE
  1. Introduction to Lipid Structure
  2. Lipid Structure and Stereochemistry
  3. Lipids in Water : Structure
  4. Dynamics of Bilayer Membranes
  5. SUPPLEMENT: REVIEW SESSION ON THERMODYNAMICS
  6. Lipids in Water: Thermodynamics
  7. Why do Single Chain Amphiphiles form Micelles not Bilayers, and Double Chain Amphiphiles from Bilayers and not Micelles?
  8. What's New in Lipid Biochemistry
Chapter 2:  PROTEIN STRUCTURE
  1. The Structure and Property of Amino Acids
  2. Composition, Sequence and Conformational Analyis of Proteins;
  3. Understanding Protein Conformation
  4. Proteins Folding - In Vivo and In Vitro
  5. Laboratory Determination of DGo for Protein Folding/Unfolding
  6. Thermodynamics and IMF's in Protein Stability
  7. Prediction of Secondary and Hydrophobic Tertiary Structure
  8. What's New in Protein Chemistry: Protein Aggregates - Not Just  Junk
  9. SUPPLEMENT: MOLECULAR MECHANICS AND DYNAMICS
Chapter 3:  CARBOHYDRATES
  1. Monosaccharides and Disssacharides
  2. Complex Oligosaccharides
  3. Jeopardy
  4. Glycoproteins:  Biosynthesis and Function
Chapter 4:  DNA, GENOMICS, AND PROTEOMICS
  1. The Structure of DNA
  2. The Central Dogma of Biology
  3. The Language of DNA
  4. Proteomics
  5. Human Genome Review
Chapter 5:  BINDING
  1. Reversible Binding I: Equations and Curves
  2. Reversible Binding II: Experimental Binding Curves, Kd, and Error Analysis
  3. A Model Binding System: Myoglobin. Hemoglobin, and Dioxygen
  4. Binding and the Control of Gene Transcription:  
  5. New Methods in Drug Development
Chapter 6:  TRANSPORT AND KINETICS
  1. Passive and Facilitated Diffusion
  2. Steady State and Rapid Equilbirum Kinetics
  3. Models of Enzyme Inhibition
  4. More Complicated Enzymes
REVIEW:  ORGANIC CHEMISTRY 

Chapter 7:  CATALYSIS

  1. Methods of catalysis
  2. Mechanisms of enzyme-catalyzed reactions
  3. Enzyme catalyzed reactions in organic solvents
  4. Ribozymes
Chapter 8:  OXIDATION/PHOSPHORYLATION
  1. The Chemistry of Dioxygen
  2. Biological Oxidation Reactions - Dehydrogenases, Mono and Dioxygenases, and Oxidases
  3. ATP and Oxidative Phosphorylation Reactions
  4. Photosynthesis: The Light Reaction
Chapter 9:  SIGNAL TRANSDUCTION
  1. Energy Transduction: Uses of ATP
  2. Signal Transduction: Nerve Cells: Neural Chemistry
  3. Signal Transduction at Cell Membranes: Protein Kinases/Phosphatases
  4. Apoptosis - Programmed Cell Death  and Signal Transduction
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